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Angiotensin Converting Enzyme 1

Function

Converts angiotensin I to angiotensin II by release of the terminal His-Leu, this results in an increase of the vasoconstrictor activity of angiotensin. Also able to inactivate bradykinin, a potent vasodilator. Has also a glycosidase activity which releases GPI-anchored proteins from the membrane by cleaving the mannose linkage in the GPI moiety. This GPIase activity seems to be crucial for the egg-binding ability of the sperm.

Post-translational modifications

Phosphorylated by CK2 on Ser-1305; which allows membrane retention.

Sequence similarities

Belongs to the peptidase M2 family.

Tissue specificity

Testis-specific isoform is expressed in spermatocytes, adult testis.

Cellular localization

  • Angiotensin-converting enzyme, soluble form
  • Secreted
  • Cell membrane
  • Single-pass type I membrane protein
  • Cytoplasm
  • Detected in both cell membrane and cytoplasm in neurons.

Alternative names

  • Angiotensin-converting enzyme
  • ACE
  • Dipeptidyl carboxypeptidase I
  • Kininase II
  • Dcp1
  • Ace

Target type

Proteins

Primary research area

Cardiovascular

Other research areas

  • Neuroscience

Molecular weight

150918Da