ACHE

GeneName

ACHE

Summary

ACHE, also known as acetylcholinesterase or Ace1, is a 68kDa enzyme primarily located at the neuromuscular junction and synaptic cleft. It is anchored to the cell membrane and plays a crucial role in the hydrolysis of the neurotransmitter acetylcholine, thereby terminating synaptic transmission and regulating cholinergic signalling. ACHE is also involved in processes such as amyloid-beta binding and collagen binding, and it contributes to various biological functions including synapse assembly and nervous system development.

Importance

ACHE is relevant to: - Neurodegenerative diseases, such as Alzheimer’s, due to its role in acetylcholine metabolism and synaptic function - Neuromuscular disorders, as it is essential for muscle contraction and neuromuscular transmission - Research on cholinergic signalling pathways, which are implicated in cognitive functions and memory - Developmental biology, particularly in the context of nervous system and retina development.

Top Products

For researchers investigating ACHE, we recommend two primary antibodies that cater to a variety of applications. The first is the well-cited polyclonal antibody, Anti-Acetylcholinesterase antibody (ab31276), which has garnered 13 citations and is highly regarded for its performance in Western blotting (WB), immunocytochemistry (ICC), and flow cytometry (FC). This product is a trusted choice for those looking to study ACHE in detail. Additionally, we offer the recombinant antibody, Anti-Acetylcholinesterase antibody [EPR23268-202] (ab253201), which is suitable for Western blotting (WB) and immunoprecipitation (IP). This recombinant product ensures batch-to-batch consistency, making it an excellent option for researchers who require reliable results in their experiments. The Anti-Acetylcholinesterase antibody [EPR23268-202] ELISA Kit (ab253201) is an excellent option for researchers looking to measure acetylcholinesterase levels in their samples.

Abcam Product Citation Summary

The data indicates that the ACHE antibody (ab31276) has been effectively used in Western blotting to study ACHE levels in human plasma samples, particularly in the context of Alzheimer's disease and cholinesterase activity. Additionally, it has been applied in studies involving human A549 cells, focusing on the effects of p53 siRNA.

Abcam Product Citation Table

Function

Hydrolyzes rapidly the acetylcholine neurotransmitter released into the synaptic cleft allowing to terminate the signal transduction at the neuromuscular junction. Role in neuronal apoptosis.

Sequence Similarities

Belongs to the type-B carboxylesterase/lipase family.

Tissue Specificity

Isoform H is highly expressed in erythrocytes.

Cellular localization

• Synapse
• Secreted
• Cell membrane
• Peripheral membrane protein
• Isoform T
• Nucleus
• Only observed in apoptotic nuclei.
• Isoform H
• Cell membrane
• Lipid-anchor
• GPI-anchor
• Extracellular side

Alternative names

Acetylcholinesterase, AChE, ACHE

Database links

swissprot:P22303 omim:100740 entrezGene:43

Other research areas

• Cardiovascular