Ache

Function

Terminates signal transduction at the neuromuscular junction by rapid hydrolysis of the acetylcholine released into the synaptic cleft.

Sequence Similarities

Belongs to the type-B carboxylesterase/lipase family.

Tissue Specificity

Predominates in most expressing tissues except erythrocytes where a glycophospholipid-attached form of ACHE predominates.

Cellular localization

• Synapse
• Secreted
• Cell membrane
• Peripheral membrane protein
• Isoform H
• Cell membrane
• Lipid-anchor
• GPI-anchor
• Extracellular side

Alternative names

Acetylcholinesterase, AChE, Ache

Database links

swissprot:P21836 entrezGene:11423

Other research areas

• Cardiovascular