ACOT13
Function
Catalyzes the hydrolysis of acyl-CoAs into free fatty acids and coenzyme A (CoASH), regulating their respective intracellular levels (PubMed:16934754, PubMed:19170545). Has acyl-CoA thioesterase activity towards medium (C12) and long-chain (C18) fatty acyl-CoA substrates (By similarity) (PubMed:16934754, PubMed:19170545). Can also hydrolyze 3-hydroxyphenylacetyl-CoA and 3,4-dihydroxyphenylacetyl-CoA (in vitro) (By similarity) (PubMed:16934754, PubMed:19170545). May play a role in controlling adaptive thermogenesis (By similarity).
Sequence Similarities
Belongs to the thioesterase PaaI family.
Cellular localization
- Cytoplasm
- Cytosol
- Mitochondrion
- Nucleus
- Cytoplasm
- Cytoskeleton
- Spindle
- During interphase, found both in the nucleus and in the cytoplasm. At mitosis, localizes to the spindle. Colocalizes with tubulin.
Alternative names
THEM2, HT012, PNAS-27, ACOT13, Acyl-coenzyme A thioesterase 13, Acyl-CoA thioesterase 13, Hotdog-fold thioesterase superfamily member 2, Palmitoyl-CoA hydrolase, Thioesterase superfamily member 2