ACOT4
Function
Catalyzes the hydrolysis of acyl-CoAs into free fatty acids and coenzyme A (CoASH), regulating their respective intracellular levels (PubMed:16940157). Functions as a peroxisomal succinyl-coenzyme A thioesterase that can also hydrolyze glutaryl-CoA and long chain saturated acyl-CoAs (PubMed:16940157).
Pathway
Lipid metabolism; fatty acid biosynthesis.
Sequence Similarities
Belongs to the C/M/P thioester hydrolase family.
Tissue Specificity
Strongest expression in liver and kidney and weaker expression in placenta, heart, and muscle.
Cellular localization
- Peroxisome
Alternative names
PTE2B, PTEIB, ACOT4, Peroxisomal succinyl-coenzyme A thioesterase, Acyl-coenzyme A thioesterase 4, PTE-2b, Peroxisomal acyl coenzyme A thioester hydrolase Ib, Peroxisomal long-chain acyl-CoA thioesterase Ib, Acyl-CoA thioesterase 4, PTE-Ib