ACOT7
Domain
Both HotDog ACOT-type hydrolase domains are required for efficient activity.
Function
Catalyzes the hydrolysis of acyl-CoAs into free fatty acids and coenzyme A (CoASH), regulating their respective intracellular levels (PubMed:10578051). Preferentially hydrolyzes palmitoyl-CoA, but has a broad specificity acting on other fatty acyl-CoAs with chain-lengths of C8-C18 (PubMed:10578051). May play an important physiological function in brain (PubMed:10578051).
Pathway
Lipid metabolism; fatty acid metabolism.
Tissue Specificity
Isoform 4 is expressed exclusively in brain.
Cellular localization
- Isoform 4
- Cytoplasm
- Cytosol
- Isoform 6
- Cytoplasm
- Cytosol
- Isoform 1
- Mitochondrion
- Isoform 5
- Mitochondrion
Alternative names
BACH, ACOT7, Cytosolic acyl coenzyme A thioester hydrolase, Acyl-CoA thioesterase 7, Brain acyl-CoA hydrolase, CTE-IIa, Long chain acyl-CoA thioester hydrolase, hBACH, CTE-II