ACP1

Function

Acts on tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and synthetic acyl phosphates with differences in substrate specificity between isoform 1 and isoform 2.

Isoform 3

Does not possess phosphatase activity.

Post-translational modifications

Isoform 2

Phosphorylated by LCK (PubMed:10336608, PubMed:9038134). Phosphorylation at Tyr-132 increases its phosphatase activity (PubMed:9038134).

Isoform 3

Not phosphorylated.

Sequence Similarities

Belongs to the low molecular weight phosphotyrosine protein phosphatase family.

Tissue Specificity

Isoform 2

Expressed in T-lymphocytes.

Cellular localization

• Cytoplasm

Alternative names

Low molecular weight phosphotyrosine protein phosphatase, LMW-PTP, LMW-PTPase, Adipocyte acid phosphatase, Low molecular weight cytosolic acid phosphatase, Red cell acid phosphatase 1, ACP1

Database links

swissprot:P24666 swissprot:P11117 swissprot:P13686 omim:171790 omim:171650 omim:171640 omim:171500 swissprot:P15309 entrezGene:55 entrezGene:54 entrezGene:53 entrezGene:52