ACP1

Acts on tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and synthetic acyl phosphates with differences in substrate specificity between isoform 1 and isoform 2.

Isoform 3

Does not possess phosphatase activity.

Isoform 2

Phosphorylated by LCK (PubMed:10336608, PubMed:9038134). Phosphorylation at Tyr-132 increases its phosphatase activity (PubMed:9038134).

Isoform 3

Not phosphorylated.

Belongs to the low molecular weight phosphotyrosine protein phosphatase family.

Isoform 2

Expressed in T-lymphocytes.

• Cytoplasm

Low molecular weight phosphotyrosine protein phosphatase, LMW-PTP, LMW-PTPase, Adipocyte acid phosphatase, Low molecular weight cytosolic acid phosphatase, Red cell acid phosphatase 1, ACP1

• entrezGene:55
• entrezGene:54
• entrezGene:53
• entrezGene:52
• omim:171790
• omim:171650
• omim:171640
• omim:171500
• swissprot:P24666
• swissprot:P11117
• swissprot:P13686
• swissprot:P15309

Proteins

Immuno-oncology

18042Da