ACP3

A non-specific tyrosine phosphatase that dephosphorylates a diverse number of substrates under acidic conditions (pH 4-6) including alkyl, aryl, and acyl orthophosphate monoesters and phosphorylated proteins. Has lipid phosphatase activity and inactivates lysophosphatidic acid in seminal plasma (By similarity).

Isoform 2

In addition to its tyrosine phosphatase activity, also has ecto-5'-nucleotidase activity in dorsal root ganglion (DRG) neurons. Generates adenosine from AMP. This extracellular adenosine leads to a decrease in chronic pain by activating A1R in nociceptive neurons.

Belongs to the histidine acid phosphatase family.

Isoform 1

Expressed in salivary gland, thymus and thyroid gland.

Isoform 2

Widely expressed in prostate lobes, brain, kidney, liver, lung, muscle, placenta, salivary gland, spleen, thyroid and thymus. Locates to Schwann cells and fibroblasts. Expressed in peptidergic and non-peptidergic nociceptive (pain-sensing) neurons. Preferentially expressed in non-peptidergic doral root ganglia neurons.

• Isoform 1
• Secreted
• Isoform 2
• Cell membrane
• Single-pass type I membrane protein
• Lysosome membrane
• Single-pass type I membrane protein
• Appears to shuttle between the cell membrane and intracellular vesicles. Colocalizes with FLOT1 at cell membrane and in intracellular vesicles (PubMed:17638863). Colocalizes with LAMP2 on the lysosome membrane (By similarity).

Acpp, Acp3, Prostatic acid phosphatase, 5'-nucleotidase, Acid phosphatase 3, Ecto-5'-nucleotidase, Fluoride-resistant acid phosphatase, Protein tyrosine phosphatase ACP3, Thiamine monophosphatase, 5'-NT, FRAP, TMPase

• entrezGene:56318
• swissprot:Q8CE08

Proteins

Oncology

43717Da