ACR
Function
Acrosin is the major protease of mammalian spermatozoa. It is a serine protease of trypsin-like cleavage specificity, it is synthesized in a zymogen form, proacrosin and stored in the acrosome.
Involvement in disease
Spermatogenic failure 87
SPGF87
An autosomal recessive male infertility disorder characterized by inability of mutant sperm to penetrate the zona pellucida, resulting in fertilization failure.
None
The disease may be caused by variants affecting the gene represented in this entry.
Sequence Similarities
Belongs to the peptidase S1 family.
Alternative names
ACRS, ACR, Acrosin