ACRBP
Function
Acrosin-binding protein, mature form
Acrosomal protein that maintains proacrosin (pro-ACR) as an enzymatically inactive zymogen in the acrosome. Involved also in the acrosome formation.
Post-translational modifications
Phosphorylated on Tyr residues in capacitated sperm.
The N-terminus is blocked.
Synthesized as a 60-kDa precursor, the 32-kDa mature form is post-translationally produced by the removal of the N-terminal half of the precursor during sperm maturation in the testis and/or epididymis.
Tissue Specificity
Expression restricted to testis in normal tissue. Expressed in a wide spectrum of cancers, including bladder, breast, liver, lung and colon cancers.
Cellular localization
- Secreted
- Cytoplasmic vesicle
- Secretory vesicle
- Acrosome
Alternative names
Acrosin-binding protein, Cancer/testis antigen 23, Cancer/testis antigen OY-TES-1, Proacrosin-binding protein sp32, CT23, ACRBP