ACSL3
Function
Acyl-CoA synthetases (ACSL) activates long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation (PubMed:22633490). Required for the incorporation of fatty acids into phosphatidylcholine, the major phospholipid located on the surface of VLDL (very low density lipoproteins) (PubMed:18003621). Has mainly an anabolic role in energy metabolism. Mediates hepatic lipogenesis. Preferentially uses myristate, laurate, arachidonate and eicosapentaenoate as substrates. Both isoforms exhibit the same level of activity (By similarity).
Sequence Similarities
Belongs to the ATP-dependent AMP-binding enzyme family.
Cellular localization
- Mitochondrion outer membrane
- Single-pass type III membrane protein
- Peroxisome membrane
- Single-pass type III membrane protein
- Microsome membrane
- Single-pass type III membrane protein
- Endoplasmic reticulum membrane
- Single-pass type III membrane protein
Alternative names
ACS3, FACL3, LACS3, ACSL3, Fatty acid CoA ligase Acsl3, Arachidonate--CoA ligase, Long-chain acyl-CoA synthetase 3, Long-chain-fatty-acid--CoA ligase 3, Medium-chain acyl-CoA ligase Acsl3, LACS 3