ACSL5
Function
Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation (PubMed:17681178, PubMed:22633490, PubMed:24269233, PubMed:33191500). ACSL5 may activate fatty acids from exogenous sources for the synthesis of triacylglycerol destined for intracellular storage (By similarity). Utilizes a wide range of saturated fatty acids with a preference for C16-C18 unsaturated fatty acids (By similarity). It was suggested that it may also stimulate fatty acid oxidation (By similarity). At the villus tip of the crypt-villus axis of the small intestine may sensitize epithelial cells to apoptosis specifically triggered by the death ligand TRAIL. May have a role in the survival of glioma cells.
Involvement in disease
Diarrhea 13
DIAR13
An autosomal recessive disorder characterized by neonatal onset of recurrent vomiting and diarrhea, leading to severe failure to thrive.
None
The disease may be caused by variants affecting the gene represented in this entry.
Sequence Similarities
Belongs to the ATP-dependent AMP-binding enzyme family.
Cellular localization
- Mitochondrion
- Endoplasmic reticulum
- Mitochondrion outer membrane
- Single-pass type III membrane protein
- Endoplasmic reticulum membrane
- Single-pass type III membrane protein
- Cell membrane
Alternative names
ACS5, FACL5, UNQ633/PRO1250, ACSL5, Long-chain-fatty-acid--CoA ligase 5, Arachidonate--CoA ligase, Long-chain acyl-CoA synthetase 5, LACS 5