ACTR5
Function
Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. Involved in DNA double-strand break repair and UV-damage excision repair.
Sequence Similarities
Belongs to the actin family. ARP5 subfamily.
Cellular localization
- Nucleus
- Cytoplasm
- Predominantly nuclear but undergoes nucleo-cytoplasmic shuttling (PubMed:19014934). Localized to interphase nuclei, but not nucleoli; excluded from chromosomes as mitosis progresses (PubMed:18163988).
Alternative names
ARP5, ACTR5, Actin-related protein 5, hARP5, Sarcoma antigen NY-SAR-16