ACY3
Function
Plays an important role in deacetylating mercapturic acids in kidney proximal tubules. Also acts on N-acetyl-aromatic amino acids (By similarity).
Sequence Similarities
Belongs to the AspA/AstE family. Aspartoacylase subfamily.
Cellular localization
- Apical cell membrane
- Peripheral membrane protein
- Cytoplasm
- Predominantly localized in the apical membrane of cells in the S1 segment. In the proximal straight tubules (S2 and S3 segments) is expressed diffusely throughout the cytoplasm.
Alternative names
ASPA2, ACY3, N-acyl-aromatic-L-amino acid amidohydrolase (carboxylate-forming), Acylase III, Aminoacylase-3, Aspartoacylase-2, Hepatitis C virus core-binding protein 1, ACY-3, HCBP1, HCV core-binding protein 1