Ada
Function
Catalyzes the hydrolytic deamination of adenosine and 2-deoxyadenosine (PubMed:19900420). Plays an important role in purine metabolism and in adenosine homeostasis (By similarity). Modulates signaling by extracellular adenosine, and so contributes indirectly to cellular signaling events (By similarity). Acts as a positive regulator of T-cell coactivation, by binding DPP4 (By similarity). Its interaction with DPP4 regulates lymphocyte-epithelial cell adhesion (By similarity). Enhances dendritic cell immunogenicity by affecting dendritic cell costimulatory molecule expression and cytokines and chemokines secretion (By similarity). Enhances CD4+ T-cell differentiation and proliferation (By similarity). Acts as a positive modulator of adenosine receptors ADORA1 and ADORA2A, by enhancing their ligand affinity via conformational change (By similarity). Stimulates plasminogen activation (By similarity). Plays a role in male fertility (By similarity). Plays a protective role in early postimplantation embryonic development (By similarity) (PubMed:19900420). Also responsible for the deamination of cordycepin (3'-deoxyadenosine), a fungal natural product that shows antitumor, antibacterial, antifungal, antivirus, and immune regulation properties (By similarity).
Sequence Similarities
Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.
Tissue Specificity
Detected in brain and liver (at protein level).
Cellular localization
- Cell membrane
- Peripheral membrane protein
- Extracellular side
- Cell junction
- Cytoplasmic vesicle lumen
- Cytoplasm
- Lysosome
- Colocalized with DPP4 at the cell surface.
Alternative names
Adenosine deaminase, Adenosine aminohydrolase, Ada