The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
Participates in the proteolytic processing of beta-type neuregulin isoforms which are involved in neurogenesis and synaptogenesis, suggesting a regulatory role in glial cell. Also cleaves alpha-2 macroglobulin. May be involved in osteoblast differentiation and/or osteoblast activity in bone (By similarity).
The precursor is cleaved by a furin endopeptidase.
Expressed in many normal organ tissues and several cancer cell lines.
MLTNB, FKSG34, ADAM19, Disintegrin and metalloproteinase domain-containing protein 19, ADAM 19, Meltrin-beta, Metalloprotease and disintegrin dendritic antigen marker, MADDAM
Proteins
Immuno-oncology
104997Da
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