ADAM19
Domain
The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
Function
Participates in the proteolytic processing of beta-type neuregulin isoforms which are involved in neurogenesis and synaptogenesis, suggesting a regulatory role in glial cell. Also cleaves alpha-2 macroglobulin. May be involved in osteoblast differentiation and/or osteoblast activity in bone (By similarity).
Post-translational modifications
The precursor is cleaved by a furin endopeptidase.
Tissue Specificity
Expressed in many normal organ tissues and several cancer cell lines.
Cellular localization
- Membrane
- Single-pass type I membrane protein
Alternative names
MLTNB, FKSG34, ADAM19, Disintegrin and metalloproteinase domain-containing protein 19, ADAM 19, Meltrin-beta, Metalloprotease and disintegrin dendritic antigen marker, MADDAM