ADCYAP1
Function
Binding to its receptor activates G proteins and stimulates adenylate cyclase in pituitary cells. Promotes neuron projection development through the RAPGEF2/Rap1/B-Raf/ERK pathway. In chromaffin cells, induces long-lasting increase of intracellular calcium concentrations and neuroendocrine secretion (By similarity). Involved in the control of glucose homeostasis, induces insulin secretion by pancreatic beta cells (By similarity).
Sequence Similarities
Belongs to the glucagon family.
Cellular localization
- Secreted
Alternative names
Pituitary adenylate cyclase-activating polypeptide, PACAP, ADCYAP1