ADD1
Domain
Each subunit is comprised of three regions: a NH2-terminal protease-resistant globular head region, a short connecting subdomain, and a protease-sensitive tail region.
Function
Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Binds to calmodulin.
Sequence Similarities
Belongs to the aldolase class II family. Adducin subfamily.
Tissue Specificity
Expressed in all tissues. Found in much higher levels in reticulocytes than the beta subunit.
Cellular localization
- Cytoplasm
- Cytoskeleton
- Cell membrane
- Peripheral membrane protein
- Cytoplasmic side
Alternative names
ADDA, ADD1, Alpha-adducin, Erythrocyte adducin subunit alpha