ADD2
Developmental stage
Fetal kidney expresses isoforms 3, 4, 5, 6 and 7, and fetal liver expresses isoforms 3 and 4.
Domain
Each subunit is comprised of three regions: a NH2-terminal protease-resistant globular head region, a short connecting subdomain, and a protease-sensitive tail region.
Function
Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Binds to the erythrocyte membrane receptor SLC2A1/GLUT1 and may therefore provide a link between the spectrin cytoskeleton to the plasma membrane. Binds to calmodulin. Calmodulin binds preferentially to the beta subunit.
Post-translational modifications
The N-terminus is blocked.
Sequence Similarities
Belongs to the aldolase class II family. Adducin subfamily.
Tissue Specificity
Expressed mainly in brain, spleen, kidney cortex and medulla, and heart. Also expressed in human umbilical vein endothelial cells, human vascular smooth muscle cells, kidney tubular cells and K-562 cell line.
Cellular localization
- Cytoplasm
- Cytoskeleton
- Cell membrane
- Peripheral membrane protein
- Cytoplasmic side
Alternative names
ADDB, ADD2, Beta-adducin, Erythrocyte adducin subunit beta