Adenylate kinase isoenzyme 5
Function
Nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Active on AMP and dAMP with ATP as a donor. When GTP is used as phosphate donor, the enzyme phosphorylates AMP, CMP, and to a small extent dCMP. Also displays broad nucleoside diphosphate kinase activity.
Sequence Similarities
Belongs to the adenylate kinase family.
Tissue Specificity
Brain specific.
Cellular localization
- Cytoplasm
Alternative names
Adenylate kinase isoenzyme 5, AK 5, ATP-AMP transphosphorylase 5, AK5