ADGRD1

Domain

A short peptide sequence (termed the Stachel sequence) in the C-terminal part of the extracellular domain (ECD) functions as a tethered agonist. Upon structural changes within the ECD, e.g. due to extracellular ligand binding or mechanical movements, this intramolecular agonist is exposed to the 7 transmembrane region, triggering G-protein activation.

The N-terminal domain and autocatalytic activity of ADGRD1 at the GPCR proteolysis site (GPS) are not required for G-protein coupling activity.

Function

Orphan receptor. Signals via G(s)-alpha family of G-proteins (PubMed:22025619, PubMed:22575658). Has protumorigenic function especially in glioblastoma (PubMed:27775701).

Sequence similarities

Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.

Tissue specificity

Up-regulated in CD133(+) cell population of glioblastoma.

Cellular localization

• Cell membrane
• Multi-pass membrane protein

Alternative names

• Adhesion G-protein coupled receptor D1
• G-protein coupled receptor 133
• G-protein coupled receptor PGR25
• ADGRD1
• GPR133
• PGR25

Database links

• entrezGene:283383
• omim:613639
• swissprot:Q6QNK2

Target type

Proteins

Molecular weight

96530Da