ADGRE1

Function

Orphan receptor involved in cell adhesion and probably in cell-cell interactions specifically involving cells of the immune system. May play a role in regulatory T-cells (Treg) development.

Sequence Similarities

Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.

Tissue Specificity

Expression is restricted to eosinophils.

Cellular localization

• Cell membrane
• Multi-pass membrane protein

Alternative names

EMR1, TM7LN3, ADGRE1, Adhesion G protein-coupled receptor E1, EGF-like module receptor 1, EGF-like module-containing mucin-like hormone receptor-like 1, EMR1 hormone receptor

Database links

swissprot:Q14246 omim:600493 entrezGene:2015

Other research areas

• Immuno-oncology
• Neuroscience