ADGRE1

Function

Orphan receptor involved in cell adhesion and probably in cell-cell interactions specifically involving cells of the immune system. May play a role in regulatory T-cells (Treg) development.

Sequence similarities

Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.

Tissue specificity

In macrophages; but absent from those which are localized within T-cell areas of lymph nodes and spleen. Low level of expression on blood monocytes.

Cellular localization

• Cell membrane
• Multi-pass membrane protein

Alternative names

• Adhesion G protein-coupled receptor E1
• Cell surface glycoprotein F4/80
• EGF-like module receptor 1
• EGF-like module-containing mucin-like hormone receptor-like 1
• EMR1 hormone receptor
• Adgre1
• Emr1
• Gpf480

Database links

• entrezGene:13733
• swissprot:Q61549

Target type

Proteins

Primary research area

Immunology & Infectious Disease

Other research areas

• Immuno-oncology
• Neuroscience

Molecular weight

102130Da