ADGRE5
Domain
The first two EGF domains mediate the interaction with DAF. A third tandemly arranged EGF domain is necessary for the structural integrity of the binding region.
Binding to chondroitin sulfate is mediated by the fourth EGF domain.
Function
Receptor potentially involved in both adhesion and signaling processes early after leukocyte activation. Plays an essential role in leukocyte migration.
Post-translational modifications
Proteolytically cleaved into 2 subunits, an extracellular alpha subunit and a seven-transmembrane subunit.
Sequence Similarities
Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily.
Tissue Specificity
Broadly expressed, found on most hematopoietic cells, including activated lymphocytes, monocytes, macrophages, dendritic cells, and granulocytes. Expressed also abundantly by smooth muscle cells. Expressed in thyroid, colorectal, gastric, esophageal and pancreatic carcinomas too. Expression are increased under inflammatory conditions in the CNS of multiple sclerosis and in synovial tissue of patients with rheumatoid arthritis. Increased expression of CD97 in the synovium is accompanied by detectable levels of soluble CD97 in the synovial fluid.
Cellular localization
- Cell membrane
- Multi-pass membrane protein
- Adhesion G protein-coupled receptor E5 subunit alpha
- Secreted
- Extracellular space
Alternative names
CD97, ADGRE5, Adhesion G protein-coupled receptor E5, Leukocyte antigen CD97