ADGRG4
Function
Orphan receptor.
Post-translational modifications
Autoproteolytically processed at the GPS region of the GAIN-B domain; this cleavage modulates receptor activity.
Sequence Similarities
Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.
Tissue Specificity
Detected in fetal retina. Highly expressed in normal enterochromaffin cells and in neuroendocrine carcinoma. Detected in normal liver; highly expressed in primary liver carcinoma.
Cellular localization
- Membrane
- Multi-pass membrane protein
Alternative names
GPR112, ADGRG4, Adhesion G-protein coupled receptor G4, G-protein coupled receptor 112