ADGRG5
Function
Adhesion G protein-coupled receptor (GPCR). Transduces intracellular signals through coupling to guanine nucleotide-binding protein G(s) subunit alpha and activation of adenylate cyclase pathway. Isoform 1, but not isoform 2, is constitutively active, as evidenced by elevated basal cAMP levels, and responds to mechanical activation (shaking).
Post-translational modifications
Autoproteolysis between residues Leu-226 and Thr-227 occurs in the lumen of the endoplasmic reticulum during receptor biosynthesis. The N-terminal fragment (NTF) subsequently reassociates with the C-terminal fragment (CTF) either in a homogeneric heterodimerization, or with another family member through heterogeneric heterodimerization. Autocatalytic cleavage is thought to be critical for the maturation, stability, trafficking, and function.
Sequence Similarities
Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.
Tissue Specificity
Expressed in immune cells. Primarily found in granulocytes. Found in eosinophils.
Cellular localization
- Cell membrane
- Multi-pass membrane protein
Alternative names
GPR114, PGR27, UNQ2524/PRO6017, ADGRG5, Adhesion G-protein coupled receptor G5, G-protein coupled receptor 114, G-protein coupled receptor PGR27