ADGRL2
Function
Calcium-independent receptor of low affinity for alpha-latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Receptor probably implicated in the regulation of exocytosis.
Post-translational modifications
Proteolytically cleaved into 2 subunits, an extracellular subunit and a seven-transmembrane subunit.
Sequence Similarities
Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.
Tissue Specificity
Expressed very widely in all normal tissues tested. Expression is variable in tumor cell lines, apparently elevated in some lines and absent or markedly reduced in others.
Cellular localization
- Membrane
- Multi-pass membrane protein
Alternative names
KIAA0786, LEC1, LPHH1, LPHN2, ADGRL2, Adhesion G protein-coupled receptor L2, Calcium-independent alpha-latrotoxin receptor 2, Latrophilin homolog 1, Latrophilin-2, Lectomedin-1, CIRL-2