ADH1B

Catalyzes the NAD-dependent oxidation of all-trans-retinol and its derivatives such as all-trans-4-hydroxyretinol and may participate in retinoid metabolism (PubMed:15369820, PubMed:16787387). In vitro can also catalyze the NADH-dependent reduction of all-trans-retinal and its derivatives such as all-trans-4-oxoretinal (PubMed:15369820, PubMed:16787387). Catalyzes in the oxidative direction with higher efficiency (PubMed:16787387). Has the same affinity for all-trans-4-hydroxyretinol and all-trans-4-oxoretinal (PubMed:15369820).

Belongs to the zinc-containing alcohol dehydrogenase family.

• Cytoplasm

ADH2, ADH1B, All-trans-retinol dehydrogenase [NAD(+)] ADH1B, Alcohol dehydrogenase 1B, Alcohol dehydrogenase subunit beta

• entrezGene:125
• omim:103720
• swissprot:P00325

Proteins

Metabolism

39855Da