ADH5

Function

Catalyzes the oxidation of long-chain primary alcohols and the oxidation of S-(hydroxymethyl) glutathione (PubMed:8460164). Also oxidizes long chain omega-hydroxy fatty acids, such as 20-HETE, producing both the intermediate aldehyde, 20-oxoarachidonate and the end product, a dicarboxylic acid, (5Z,8Z,11Z,14Z)-eicosatetraenedioate (PubMed:16081420). Class-III ADH is remarkably ineffective in oxidizing ethanol (PubMed:8460164).

Sequence similarities

Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily.

Cellular localization

• Cytoplasm

Alternative names

• Alcohol dehydrogenase class-3
• Alcohol dehydrogenase 5
• Alcohol dehydrogenase class chi chain
• Alcohol dehydrogenase class-III
• Glutathione-dependent formaldehyde dehydrogenase
• S-(hydroxymethyl)glutathione dehydrogenase
• FALDH
• FDH
• GSH-FDH
• ADHX
• ADH5
• FDH

Database links

• entrezGene:128
• omim:103710
• swissprot:P11766

Target type

Proteins

Molecular weight

39724Da