ADI1

Function

Catalyzes 2 different reactions between oxygen and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site (By similarity). Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4-methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway (PubMed:15938715). Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity). Also down-regulates cell migration mediated by MMP14 (PubMed:14718544). Necessary for hepatitis C virus replication in an otherwise non-permissive cell line (PubMed:11602742).

Pathway

Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 5/6.

Sequence Similarities

Belongs to the acireductone dioxygenase (ARD) family.

Tissue Specificity

Detected in heart, colon, lung, stomach, brain, spleen, liver, skeletal muscle and kidney.

Cellular localization

• Cytoplasm
• Nucleus
• Cell membrane
• Peripheral membrane protein
• Cytoplasmic side
• Localizes to the plasma membrane when complexed to MMP14.

Alternative names

MTCBP1, HMFT1638, ADI1, Acireductone dioxygenase, Acireductone dioxygenase (Fe(2+)-requiring), Acireductone dioxygenase (Ni(2+)-requiring), Membrane-type 1 matrix metalloproteinase cytoplasmic tail-binding protein 1, Submergence-induced protein-like factor, ARD', Fe-ARD, ARD, Ni-ARD, MTCBP-1, Sip-L

Database links

swissprot:Q9BV57 omim:613400 ncbi:NP_060739.2 entrezGene:55256