Adiponectin receptor protein 2

The N-terminus is cytoplasmic and the C-terminus is extracellular, contrary to what is observed for G-protein coupled receptors. Unlike G-protein coupled receptors, transmembrane helices are not kinked or tilted relative to the plane of the membrane.

Receptor for ADIPOQ, an essential hormone secreted by adipocytes that regulates glucose and lipid metabolism (PubMed:12802337, PubMed:25855295). Required for normal body fat and glucose homeostasis. ADIPOQ-binding activates a signaling cascade that leads to increased PPARA activity, and ultimately to increased fatty acid oxidation and glucose uptake. Has intermediate affinity for globular and full-length adiponectin. Required for normal revascularization after chronic ischemia caused by severing of blood vessels (By similarity).

Belongs to the ADIPOR family.

Ubiquitous (PubMed:16044242). Highly expressed in skeletal muscle, liver and placenta (PubMed:12802337). Weakly expressed in brain, heart, colon, spleen, kidney, thymus, small intestine, peripheral blood leukocytes and lung (PubMed:12802337).

• Cell membrane
• Multi-pass membrane protein
• Localized to the cell membrane and intracellular organelles.

PAQR2, ADIPOR2, Adiponectin receptor protein 2, Progestin and adipoQ receptor family member 2, Progestin and adipoQ receptor family member II

• entrezGene:79602
• omim:607946
• swissprot:Q86V24

Proteins

Metabolism

43884Da