ADORA2A
Domain
The cytoplasmic C-terminal domain is necessary for targeting the non-ubiquitinated form of this protein to the cell surface.
Function
Receptor for adenosine (By similarity). The activity of this receptor is mediated by G proteins which activate adenylyl cyclase (By similarity).
Post-translational modifications
Ubiquitinated. Deubiquitinated by USP4; leading to stabilization and expression at the cell surface.
Sequence Similarities
Belongs to the G-protein coupled receptor 1 family.
Cellular localization
- Cell membrane
- Multi-pass membrane protein
- Colocalizes with GAS2L2 at neuronal processes.
Alternative names
ADORA2, ADORA2A, Adenosine receptor A2a