beta 1 Adrenergic Receptor

The PDZ domain-binding motif mediates competitive interactions with GOPC, MAGI3 and DLG4 and plays a role in subcellular location of the receptor.

Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. This receptor binds epinephrine and norepinephrine with approximately equal affinity. Mediates Ras activation through G(s)-alpha- and cAMP-mediated signaling. Involved in the regulation of sleep/wake behaviors (PubMed:31473062).

Homologous desensitization of the receptor is mediated by its phosphorylation by beta-adrenergic receptor kinase.

Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRB1 sub-subfamily.

• Cell membrane
• Multi-pass membrane protein
• Early endosome
• Colocalizes with RAPGEF2 at the plasma membrane (By similarity). Localized at the plasma membrane. Found in the Golgi upon GOPC overexpression.

ADRB1R, B1AR, ADRB1, Beta-1 adrenergic receptor, Beta-1 adrenoreceptor, Beta-1 adrenoceptor

• entrezGene:153
• omim:109630
• swissprot:P08588

Proteins

Cardiovascular

51323Da