Adrb1
Domain
The PDZ domain-binding motif mediates competitive interactions with GOPC, MAGI3 and DLG4 and plays a role in subcellular location of the receptor.
Function
Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. This receptor binds epinephrine and norepinephrine with approximately equal affinity. Mediates Ras activation through G(s)-alpha- and cAMP-mediated signaling (By similarity). Involved in the regulation of sleep/wake behaviors (PubMed:31473062).
Post-translational modifications
Homologous desensitization of the receptor is mediated by its phosphorylation by beta-adrenergic receptor kinase.
Sequence Similarities
Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRB1 sub-subfamily.
Tissue Specificity
In brain, expressed by glutamatergic and GABAergic neurons of the dorsal pons (at protein level).
Cellular localization
- Cell membrane
- Multi-pass membrane protein
- Early endosome
- Colocalizes with RAPGEF2 at the plasma membrane. Found in the Golgi upon GOPC overexpression (By similarity).
Alternative names
Adrb1r, Beta-1 adrenergic receptor, Beta-1 adrenoreceptor, Beta-1 adrenoceptor