ADTRP
Function
Hydrolyzes bioactive fatty-acid esters of hydroxy-fatty acids (FAHFAs), but not other major classes of lipids (PubMed:27018888). Show a preference for FAHFAs with branching distal from the carboxylate head group of the lipids (PubMed:27018888). Regulates the expression and the cell-associated anticoagulant activity of the inhibitor TFPI in endothelial cells (in vitro) (PubMed:21868574).
Sequence Similarities
Belongs to the AIG1 family.
Tissue Specificity
Expressed in cultured endothelial cells and in placenta.
Cellular localization
- Cell membrane
- Multi-pass membrane protein
- Colocalized with TFPI and CAV1 in lipid rafts.
Alternative names
C6orf105, ADTRP, Androgen-dependent TFPI-regulating protein, Fatty acid esters of hydroxy fatty acids hydrolase ADTRP, FAHFA hydrolase ADTRP