AEBP2

Function

Acts as an accessory subunit for the core Polycomb repressive complex 2 (PRC2), which mediates histone H3K27 (H3K27me3) trimethylation on chromatin leading to transcriptional repression of the affected target gene (PubMed:15225548, PubMed:29499137, PubMed:31959557). Plays a role in nucleosome localization of the PRC2 complex (PubMed:29499137).

Sequence Similarities

Belongs to the AEBP2/jing C2H2-type zinc-finger family.

Cellular localization

• Nucleus
• Localizes to chromatin as part of the PRC2 complex.

Alternative names

Zinc finger protein AEBP2, Adipocyte enhancer-binding protein 2, AE-binding protein 2, AEBP2

Database links

swissprot:Q6ZN18 omim:602923 entrezGene:121536 entrezGene:23512 entrezGene:5928 entrezGene:8726 entrezGene:2145 swissprot:Q92800 swissprot:Q09028 swissprot:Q15022 swissprot:O75530 omim:605984 omim:601674 omim:606245