AFF1
Involvement in disease
A chromosomal aberration involving AFF1 is associated with acute leukemias. Translocation t(4;11)(q21;q23) with KMT2A/MLL1. The result is a rogue activator protein.
Sequence Similarities
Belongs to the AF4 family.
Cellular localization
- Nucleus
Alternative names
AF4, FEL, MLLT2, PBM1, AFF1, AF4/FMR2 family member 1, ALL1-fused gene from chromosome 4 protein, Protein FEL, Proto-oncogene AF4, Protein AF-4