Occurs in the plasma of fetuses more than 4 weeks old, reaches the highest levels during the 12th-16th week of gestation, and drops to trace amounts after birth. The serum level in adults is usually less than 40 ng/ml. AFP occurs also at high levels in the plasma and ascitic fluid of adults with hepatoma.
Binds copper, nickel, and fatty acids as well as, and bilirubin less well than, serum albumin. Only a small percentage (less than 2%) of the human AFP shows estrogen-binding properties.
Alpha-fetoprotein deficiency
AFPD
A benign condition characterized by undetectable AFP levels in the amniotic fluid. Affected individuals are asymptomatic and present normal development.
None
The disease is caused by variants affecting the gene represented in this entry.
Alpha-fetoprotein, hereditary persistence
HPAFP
A benign autosomal dominant condition characterized by continued expression of alpha-fetoprotein in adult life.
None
The disease is caused by variants affecting the gene represented in this entry.
Independent studies suggest heterogeneity of the N-terminal sequence of the mature protein and of the cleavage site of the signal sequence.
Sulfated.
Belongs to the ALB/AFP/VDB family.
Plasma. Synthesized by the fetal liver and yolk sac.
HPAFP, AFP, Alpha-fetoprotein, Alpha-1-fetoprotein, Alpha-fetoglobulin
Proteins
Immuno-oncology
68678Da
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