AGAP1
Domain
The PH domain mediates AP-3 binding.
Function
GTPase-activating protein for ARF1 and, to a lesser extent, ARF5. Directly and specifically regulates the adapter protein 3 (AP-3)-dependent trafficking of proteins in the endosomal-lysosomal system.
Post-translational modifications
Phosphorylated on tyrosines.
Sequence Similarities
Belongs to the centaurin gamma-like family.
Tissue Specificity
Widely expressed.
Cellular localization
- Cytoplasm
- Associates with the endocytic compartment.
Alternative names
CENTG2, KIAA1099, AGAP1, AGAP-1, Centaurin-gamma-2, GTP-binding and GTPase-activating protein 1, Cnt-g2, GGAP1