AGBL2

Metallocarboxypeptidase that mediates deglutamylation of tubulin and non-tubulin target proteins. Catalyzes the removal of polyglutamate side chains present on the gamma-carboxyl group of glutamate residues within the C-terminal tail of tubulin protein. Specifically cleaves tubulin long-side-chains, while it is not able to remove the branching point glutamate. Also catalyzes the removal of polyglutamate residues from the carboxy-terminus of non-tubulin proteins such as MYLK.

Belongs to the peptidase M14 family.

• Cytoplasm
• Cytosol
• Cytoplasm
• Cytoskeleton
• Microtubule organizing center
• Centrosome
• Centriole
• Cytoplasm
• Cytoskeleton
• Cilium basal body
• Colocalizes with gamma-tubulin in the centrioles and with glutamylated tubulin in the basal bodies of ciliated cells.

CCP2, AGBL2, Cytosolic carboxypeptidase 2, ATP/GTP-binding protein-like 2, Protein deglutamylase CCP2

• entrezGene:79841
• swissprot:Q5U5Z8

Proteins

Immuno-oncology

104194Da