AGFG1
Domain
Contains FG repeats. The FG repeat region is required for acting as a cofactor of HIV-1 Rev.
Function
Required for vesicle docking or fusion during acrosome biogenesis (By similarity). May play a role in RNA trafficking or localization. In case of infection by HIV-1, acts as a cofactor for viral Rev and promotes movement of Rev-responsive element-containing RNAs from the nuclear periphery to the cytoplasm. This step is essential for HIV-1 replication.
Post-translational modifications
O-glycosylated.
Tissue Specificity
Ubiquitously expressed.
Cellular localization
- Nucleus
- Cytoplasmic vesicle
Alternative names
HRB, RAB, RIP, AGFG1, Arf-GAP domain and FG repeat-containing protein 1, HIV-1 Rev-binding protein, Nucleoporin-like protein RIP, Rev-interacting protein, Rev/Rex activation domain-binding protein