Hydrolyzes linear guanidino acids to form urea and the corresponding amines. Displays specificity for substrates having a negatively charged head group and short chains including taurocyamine, guanidino propanoic and butanoic acids. May protect cells by detoxifying potentially harmful amounts of guanidino acids. Metabolizes L-arginine with low efficiency.
Nitrogen metabolism; urea cycle; L-ornithine and urea from L-arginine: step 1/1.
Belongs to the ureohydrolase superfamily. Arginase family.
Highly expressed in liver and kidney. Also found in skeletal muscle, fetal liver, brain, testis, skin and the gastrointestinal tract. Within brain, expression is higher in the cerebral cortex with lower levels in the medulla and spinal cord.
GDAH, AGMAT
Proteins
Immuno-oncology
37660Da
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