AGPAT1

The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.

Converts 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone.

Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 2/3.

Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.

Widely expressed. Expressed in adipose tissue and at high levels in testis and pancreas. Expressed at lower levels in tissues such as heart, brain, placenta, kidney, lung, spleen, thymus, prostate, ovary, intestine, colon, leukocyte and liver.

• Endoplasmic reticulum membrane
• Multi-pass membrane protein

G15, AGPAT1, 1-acyl-sn-glycerol-3-phosphate acyltransferase alpha, 1-acylglycerol-3-phosphate O-acyltransferase 1, Lysophosphatidic acid acyltransferase alpha, Protein G15, 1-AGP acyltransferase 1, 1-AGPAT 1, LPAAT-alpha

• entrezGene:10554
• omim:603099
• swissprot:Q99943

Proteins

Metabolism

31717Da