AGPAT4
Domain
The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.
Function
Converts 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone (By similarity). Exhibits high acyl-CoA specificity for polyunsaturated fatty acyl-CoA, especially docosahexaenoyl-CoA (22:6-CoA, DHA-CoA) (By similarity).
Pathway
Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 2/3.
Sequence Similarities
Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.
Tissue Specificity
Widely expressed with highest levels in skeletal muscle, followed by heart, liver, prostate and thymus.
Cellular localization
- Endoplasmic reticulum membrane
- Multi-pass membrane protein
Alternative names
UNQ499/PRO1016, AGPAT4, 1-acyl-sn-glycerol-3-phosphate acyltransferase delta, 1-acylglycerol-3-phosphate O-acyltransferase 4, Lysophosphatidic acid acyltransferase delta, 1-AGP acyltransferase 4, 1-AGPAT 4, LPAAT-delta