AGRP
Domain
The presence of a 'disulfide through disulfide knot' structurally defines this protein as a knottin.
Function
Plays a role in weight homeostasis. Involved in the control of feeding behavior through the central melanocortin system. Acts as alpha melanocyte-stimulating hormone antagonist by inhibiting cAMP production mediated by stimulation of melanocortin receptors within the hypothalamus and adrenal gland. Has very low activity with MC5R (By similarity). Is an inverse agonist for MC3R and MC4R being able to suppress their constitutive activity. It promotes MC3R and MC4R endocytosis in an arrestin-dependent manner.
Involvement in disease
Obesity
OBESITY
A condition characterized by an increase of body weight beyond the limitation of skeletal and physical requirements, as the result of excessive accumulation of body fat.
None
Disease susceptibility is associated with variants affecting the gene represented in this entry.
Tissue Specificity
Expressed primarily in the adrenal gland, subthalamic nucleus, and hypothalamus, with a lower level of expression occurring in testis, lung, and kidney.
Cellular localization
- Secreted
- Golgi apparatus lumen
Alternative names
AGRT, ART, AGRP, Agouti-related protein