AGTRAP
Function
Appears to be a negative regulator of type-1 angiotensin II receptor-mediated signaling by regulating receptor internalization as well as mechanism of receptor desensitization such as phosphorylation. Induces also a decrease in cell proliferation and angiotensin II-stimulated transcriptional activity.
Tissue Specificity
Ubiquitous but more abundant in kidney, heart, pancreas and thyroid.
Cellular localization
- Endoplasmic reticulum membrane
- Multi-pass membrane protein
- Golgi apparatus membrane
- Multi-pass membrane protein
- Cytoplasmic vesicle membrane
- Multi-pass membrane protein
- Present in perinuclear vesicular membranes, Endoplasmic reticulum, Golgi and endocytic vesicles.
Alternative names
ATRAP, AGTRAP, Type-1 angiotensin II receptor-associated protein, AT1 receptor-associated protein