AHCTF1

Domain

The N-terminus forms a highly conserved seven-bladed beta propeller decorated with long loops and mediates anchorage to the Nup107-160 subcomplex of the nuclear pore, synergistically with the central alpha domain. The disordered C-terminus is responsible for the interactions with chromatin (By similarity).

Function

Required for the assembly of a functional nuclear pore complex (NPC) on the surface of chromosomes as nuclei form at the end of mitosis. May initiate NPC assembly by binding to chromatin and recruiting the Nup107-160 subcomplex of the NPC. Also required for the localization of the Nup107-160 subcomplex of the NPC to the kinetochore during mitosis and for the completion of cytokinesis.

Sequence Similarities

Belongs to the ELYS family.

Cellular localization

• Cytoplasm
• Nucleus
• Nucleus envelope
• Nucleus matrix
• Chromosome
• Centromere
• Kinetochore
• Nucleus
• Nucleoplasm
• Nucleus
• Nuclear pore complex
• Localizes to the nuclear pore complex (NPC) throughout interphase. Localizes to the kinetochore from prophase, and this appears to require the Nup107-160 subcomplex of the NPC. Localizes to the periphery of chromatin from late anaphase.

Alternative names

ELYS, TMBS62, MSTP108, AHCTF1, Protein ELYS, Embryonic large molecule derived from yolk sac, Protein MEL-28, Putative AT-hook-containing transcription factor 1

Database links

swissprot:Q8WYP5 entrezGene:25909 swissprot:Q8IZA4 omim:610853