Ahsa1
Function
Acts as a co-chaperone of HSP90AA1 (PubMed:29127155). Activates the ATPase activity of HSP90AA1 leading to increase in its chaperone activity (PubMed:29127155). Competes with the inhibitory co-chaperone FNIP1 for binding to HSP90AA1, thereby providing a reciprocal regulatory mechanism for chaperoning of client proteins (By similarity). Competes with the inhibitory co-chaperone TSC1 for binding to HSP90AA1, thereby providing a reciprocal regulatory mechanism for chaperoning of client proteins (PubMed:29127155).
Post-translational modifications
Phosphorylation at Tyr-223 enhances binding to chaperone HSP90AA1.
Sequence Similarities
Belongs to the AHA1 family.
Cellular localization
- Cytoplasm
- Cytosol
- Endoplasmic reticulum
- May transiently interact with the endoplasmic reticulum.
Alternative names
Activator of 90 kDa heat shock protein ATPase homolog 1, AHA1, Ahsa1