AHA1

Acts as a co-chaperone of HSP90AA1 (PubMed:29127155). Activates the ATPase activity of HSP90AA1 leading to increase in its chaperone activity (PubMed:29127155). Competes with the inhibitory co-chaperone FNIP1 for binding to HSP90AA1, thereby providing a reciprocal regulatory mechanism for chaperoning of client proteins (PubMed:27353360). Competes with the inhibitory co-chaperone TSC1 for binding to HSP90AA1, thereby providing a reciprocal regulatory mechanism for chaperoning of client proteins (PubMed:29127155).

Phosphorylation at Tyr-223 enhances binding to chaperone HSP90AA1.

Belongs to the AHA1 family.

Expressed in numerous tissues, including brain, heart, skeletal muscle and kidney and, at lower levels, liver and placenta.

• Cytoplasm
• Cytosol
• Endoplasmic reticulum
• May transiently interact with the endoplasmic reticulum.

C14orf3, HSPC322, AHSA1, Activator of 90 kDa heat shock protein ATPase homolog 1, AHA1, p38

• entrezGene:10598
• omim:608466
• swissprot:O95433

Proteins

38274Da