AHSG
GeneName
AHSG
Summary
AHSG, also known as Fetuin A, alpha 2 HS glycoprotein, or BSP, is a 39 kDa glycoprotein primarily secreted by the liver and found in various tissues. It is present in the extracellular matrix and is associated with blood microparticles and exosomes. AHSG functions as an inhibitor of various proteolytic enzymes, including cysteine-type endopeptidases and kinases, and plays a role in regulating bone mineralization and inflammatory responses. Additionally, it is involved in the acute-phase response and has been implicated in processes such as ossification and the development of the skeletal system.
Importance
AHSG is relevant to: - The regulation of bone mineralization, which has implications for osteoporosis and other skeletal disorders. - The modulation of insulin receptor signalling, potentially influencing metabolic conditions like diabetes. - The inflammatory response, making it a candidate for studying chronic inflammatory diseases. - The acute-phase response, which is crucial in understanding systemic responses to injury and infection.
Top Products
For researchers investigating AHSG, we recommend two excellent primary antibodies. The first is the well-cited polyclonal antibody, Anti-AHSG antibody (ab112528), which has garnered 5 citations and is highly effective for Western blotting (WB). Additionally, we offer the recombinant antibody, Anti-Fetuin A antibody [EPR9291] (ab137125), which is also validated for WB and has 4 citations. This recombinant option provides the added benefit of batch-to-batch consistency, making it a reliable choice for your research needs. The Human Fetuin-A ELISA Kit (ab269372) is an excellent option for researchers looking to measure AHSG levels in their samples.
Abcam Product Citation Summary
The data indicates that AHSG is primarily studied in human contexts, particularly in relation to various cellular processes such as microtubule organisation, autophagy, cell growth inhibition, and gestational diabetes mellitus. The use of multiple applications, including ELISA and Western blotting, highlights the importance of AHSG in both tissue and serum analyses.
Abcam Product Citation Table
Function
Promotes endocytosis, possesses opsonic properties and influences the mineral phase of bone. Shows affinity for calcium and barium ions.
Involvement in disease
Alopecia-intellectual disability syndrome 1
APMR1
A rare autosomal recessive form of alopecia. APMR1 patients show loss of hair on the scalp, absence of eyebrows, eyelashes, axillary and pubic hair, and mild to severe intellectual disability.
None
The disease may be caused by variants affecting the gene represented in this entry.
Post-translational modifications
Phosphorylated by FAM20C in the extracellular medium.
O- and N-glycosylated. O-glycosylated with core 1 or possibly core 8 glycans. N-glycan at Asn-156: Hex5HexNAc4; N-glycan heterogeneity at Asn-176: Hex5HexNAc4 (major) and Hex6HexNAc5 (minor).
Sequence Similarities
Belongs to the fetuin family.
Tissue Specificity
Synthesized in liver and selectively concentrated in bone matrix. Secreted in plasma. It is also found in dentin in much higher quantities than other plasma proteins.
Cellular localization
- Secreted
Alternative names
FETUA, PRO2743, AHSG, Alpha-2-HS-glycoprotein, Alpha-2-Z-globulin, Ba-alpha-2-glycoprotein, Fetuin-A
Database links
swissprot:P02765 entrezGene:197 omim:138680 entrezGene:26998 swissprot:Q9UGM5 omim:605954